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Teacher 2011

Infectious diseases - diseases

Age range 11-14 Age range 14-16 Age range 16-19

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HIV/AIDS

Human immune deficiency virus and acquired immune deficiency syndrome

Acquired Immune Deficiency Syndrome (AIDS) is the medical term for a combination of illnesses that result when the immune system is weakened or destroyed. It is the advanced form of Human Immunodeficiency Virus (HIV), an infection that attacks the immune system, making the sufferer susceptible to other diseases. The human immune system  is made up of special cells which protect the body from infection. Normally when a virus enters the body, the immune produce antibodies which destroy or inactivate the pathogen. The immune systems of sufferers of HIV/AIDS do not function in this way because the virus attacks and affects the immune cells themselves.

HIV on a lymphocyte

The image above shows HIV attacking an immune cell

Transmission

HIV, the virus that leads to AIDS, can be spread through four bodily fluids:
• Blood
• Semen
• Vaginal secretions
• Breast milk

HIV cannot be transmitted from an infected person to you through coughing, sneezing, nose bleeds, sweat and tears, eating utensils, hugging, touching, shaking hands, sharing beds, toilets, swimming pools or mosquito bites. Neither can it be transmitted through living or going to school with an infected person.

The virus can only be spread from an infected person if their bodily fluids enter the bloodstream of an uninfected person. Sexual transmission occurs through unprotected heterosexual or homosexual sex with an infected partner. An HIV infected mother can infect her baby during pregnancy, at birth or through breast feeding. This is called vertical transmission. Blood to blood transmission can occur if infected blood is accidentally transfused to an infected patient. Transmission by non-sterile equipment, sharing non-sterilised needles or syringes (or razors), may also lead to infection. Needles used for injecting narcotics, medicine, in tattooing or piercing may also transmit blood contaminated with HIV.

An individual can become infected from only one exposure. Once infected you can infect others.

Signs and symptoms

There are four main stages to the progression of HIV/AIDS. The first stage appears  3-12 weeks after you have become infected. In this before any symptoms show it may not be possible to detect the infection with a test. This is because the body has not produced enough antibodies to be picked up by a test. The test results will therefore show a false negative. People who think they may have been infected and receive a negative test result should do a second test three months later to be absolutely sure of their HIV status. During the waiting period they should either abstain from sex or use a condom properly at all times so as not to risk exposure to the virus, or risk infecting anyone else. 

After about three months some people start to feel unwell – symptoms include fevers, headaches, tiredness, and swollen glands, but not everyone infected with HIV feels ill. But by about 3 months after infection, HIV antibodies appear in your blood - you become HIV positive

About 10% of people will rapidly progress to  from HIV infection to full blown AIDS in 2-3 years, but it can take 20 years or more before the symptoms of the disease begin to appear if modern drugs are used to keep it under control.
During this time the virus replicates rapidly, infecting the cells of the immune system.
As the immune system weakens, an infected person may develop persistent signs and symptoms (relatively mild at first), including swollen lymph glands, night sweats, fever, cough, diarrhoea, and/or weight loss.

The clinical signs and symptoms of the final stages of the AIDS include:
• Extreme fatigue
• Rapid weight loss from an unknown cause
• Appearance of swollen or tender glands in the neck, armpits or groin
• Unexplained shortness of breath, frequently accompanied by a dry cough
• Infections such as TB and pneumonia
• Persistent diarrhoea
• Intermittent high fever
• Appearance of one or more purple spots on the surface of the skin, inside the mouth, anus or nasal passages caused by a rare cancer, Karposi’s sarcoma
• Whitish coating on the tongue, throat or vagina as fungal infections take hold
• Forgetfulness, confusion and other signs of mental confusion

HIV in tissue sample

Treatment

AIDS is caused by the human immunodeficiency virus (HIV). The virus mutates frequently, this makes development of a vaccine very difficult. There is currently no effective vaccine to prevent HIV infection.

Antiretroviral medications are used to control the reproduction of the virus and slow the progression of HIV-related disease and they can stop people becoming ill for many years. Different medicines are often given in combination to prevent resistance and increase the effectiveness of treatment. It is thanks to many viral treatments that people infected with HIV can now live normal lives.
People with AIDS may develop secondary infections. Bacterial infections can be treated with antibiotics, the fungal infections with antifungal drugs and any anaemia with iron and transfusions. A healthy lifestyle, with a good balanced diet, regular exercise, no smoking or illegal drug use, and drinking alcohol in moderation if at all can all help to keep an infected person well for as long as possible.

Anti-HIV medications do not cure HIV infection and individuals taking these medications can still transmit HIV to others. They can however lengthen the time an infected person can enjoy a healthy, active life. The earlier the drugs are started, the more effectively they lengthen the lifespan of an HIV positive individual.

Preventing infection

The most effective ways of reducing or halting the spread of HIV/AIDS involve changing the way people behave, particularly in sexual relationships.
• Always use a condom to minimise the risk of infection
• Ideally everyone would have an HIV test at the start of a new relationship.
• Being faithful within marriage or a relationship
• Reduce the number of sexual partners
• Avoid the use of substances, such as alcohol, which can impair your judgement in a given situation.
• Never use intravenous drugs for recreation or share needles between drug users.
• Blood and the body fluids as well as body refuse must be handled carefully in hospitals and clinics. Blood for transfusions must be thoroughly screened for HIV antibodies.
• Pregnant women must be screened and if they are HIV positive, given drugs to reduce the risk of infecting the unborn child. Caesarean deliveries are advised, and HIV positive mothers should bottle feed their babies if at all possible as the virus can pass through to the baby in the breast milk.

Most of all, people around the world need to be educated about the risks of HIV/AIDS, how it is passed on and how to avoid it.


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