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Monoclonal antibodies are antibodies which are made to target particular cells or chemicals in the body. Some lymphocytes (called B lymphocytes) make antibodies but cannot divide. Scientists combine mouse B lymphocytes which have been stimulated to make a particular antibody with a type of tumour cell to make a cell called a hybridoma.
Hybridoma cells can both make a specific antibody and divide. The hybridoma cells are cloned to make a large number of identical cells which all make the same antibodies. The antibodies are collected and purified. These are monoclonal antibodies - antibodies from a single clone of cells
Making monoclonal antibodies
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