human genome
home page

Alcoholism and the genes

Alcoholism is a big problem in many areas of the world. There are real difficulties for the alcoholic themselves, and they may well be unable to hold down a job, drive or operate machinery safely. They also have a raised risk of liver damage, heart disease and loss of motor control. Suicide is much more common in alcoholics than in the general population.

sufferingThe families of alcoholics are affected too. They are more likely to suffer abuse, neglect and divorce. Many road accidents are linked to drink-driving, and much of the crime that is committed is either carried out under the influence of drink or to get money to buy drink. It is estimated that between 10 and 15% of the American population is alcoholic – and the UK figures are not so very different. The cost of this problem is enormous in every way.

Results from the Human Genome Project as well as from other studies suggest that there is a genetic tendency to become an alcoholic. At least two genes seem to be involved, but alcoholism is not just genetic. Environment plays an important part as well. Obviously if you never drink alcohol, you won’t become an alcoholic however strong your genetic tendency to do so!

Each of the two genes which seem to be involved has two alleles – a non-alcoholic and an alcoholic form. How likely you are to become an alcoholic if you start to drink will depend at least in part on which combination of alleles you have inherited from your parents.

Activity
Imagine a situation where it is proposed to pass a law requiring everyone to be tested for their genetic status with respect to alcoholism. As a result of this law :
  • those people who have three or four ‘alcoholic’ alleles would have their driving licence marked or carry a card which shows their status;
  • it would be illegal to sell alcohol to anyone possessing a marked licence or card;
  • anyone with a marked licence or card found buying alcohol would be banned from driving for 3 years;
  • anyone found selling alcohol to an individual with a marked licence or card would be fined £25,000.

MPs proposing this law say it would reduce the level of alcoholism by preventing those most at risk from buying and consuming alcohol. At the same time this would reduce the NHS bill for treating alcohol related disease, reduce road traffic accidents, crime, suicides, wife beating, child abuse and neglect as well as lowering the divorce rates. They claim that all of these changes would benefit individuals and society as a whole, as well as reducing government spending.

However there are strong objections to this proposal from people who see this as the thin end of the wedge, removing people’s freedom of choice. They ask: "what else will we be forbidden to do because of the information in our genes?"

Other people want to know who will have the right to information showing that an individual has alcoholic tendencies – employers, potential partners, doctors, banks, insurers, mortgage lenders …? They fear that the information in the genes, which only expresses a tendency and does not mean an individual WILL become an alcoholic, will be abused to prevent people getting work, buying a home, getting insurance … Who will decide who is allowed access to this information?

Work in a small group. Plan a report for a local TV station explaining the idea of this new law, and communicating arguments both for and against the proposed legislation. If possible, present the outcome of your work as an actual report, using sound and video.


back human genome home