Understanding the human genome can
be seen as the key to understanding the mystery of human life itself.
the Human Genome Project set out to identify (map) all of the genes
in the human chromosomes (around 30 000 of them) and to sequence
the 3 billion base pairs which make up the human DNA. The project
was set up in 1990, and involved scientists working in 18 different
countries. This international involvement is very important – knowledge
of the human genome should belong to everyone.
Who
provided the DNA that was analysed? No-one really knows, although
it is known that a group of volunteers gave samples, some of which
were then chosen anonymously and at random for all the scientists
to work with.
The project also had specific aims about the storage and analysis
of all the data involved, and consideration of the ethical, legal
and social issues which are inevitably raised when such personal
genetic information is unravelled was also part of the brief. The
project has cost around 2.7 billion US dollars, and has shown that
every individual has at least 99.9% of their DNA in common.
When the Human Genome Project was first launched, scientists worked
on mapping the individual genes, and then as technology developed
they moved on to sequencing the DNA in detail. It was thought it
would take 15 years to complete the project, but technology moved
on so fast that the genome was sequenced in 2003, two years ahead
of schedule. Two automated processes which were developed had a
major impact on the success of the project. These were the polymerase
chain reaction and DNA sequencing.
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