The biopharmaceutical industry is constantly developing new medicines. Pharmaceutical companies invest around £11m a day in Research and Development (R&D). R&D spending by the UK pharmaceutical industry is much higher than that of other industries.
The medicine development process
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Teams of chemists, pharmacologists and biologists search for molecules with medicinal properties. Molecular structures are altered to optimise activity and minimise unwanted side effects.
A technique called high-throughput screening has automated many of the initial tests and pharmaceutical laboratories may now screen thousands of compounds per week. Research chemists can use computers to model designer molecules and using the latest equipment, large pharmaceutical companies may synthesise and screen 300,000 molecules a year.
At this pre-clinical development phase, additional tests are carried out. These include animal tests to check that the chemical compound is not poisonous and chemical tests to show that it is stable enough to be used as a medicine.
Promising medicines then pass on to the clinical development phase.
For every new medicine that passes all the trials over 5,000 compounds need to be screened. On average It takes an amazing eleven years of development and, in 2014, cost £1.15 billion for each new medicine that reaches the patient.
In 2016 there were over 7000 medicines in development to treat diseases such as cancer, diabetes and infectious diseases.
Find out about the different ways of delivering a medicine through this animation.
The formulation of a medicine is how it’s made up. For example, tablets and ointment are both types of formulation. The formulation depends on several factors including:
Look at the medicines development timeline at the top of this page. Some of the phrases have the meanings shown below. Choose the phrase with the given meaning.
1. Helps heal disease
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tissue
excretion
therapeutic
clinical trials
placebo
tissue
(The correct answer is: 'therapeutic') ![]()
excretion
(The correct answer is: 'therapeutic') ![]()
therapeutic
![]()
clinical trials
(The correct answer is: 'therapeutic') ![]()
placebo
(The correct answer is: 'therapeutic') ![]() |
2. An inactive medicine given to patients on a trial
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tissue
excretion
therapeutic
clinical trials
placebo
tissue
(The correct answer is: 'placebo') ![]()
excretion
(The correct answer is: 'placebo') ![]()
therapeutic
(The correct answer is: 'placebo') ![]()
clinical trials
(The correct answer is: 'placebo') ![]()
placebo
![]() |
3. A collection of living cells that respond as though they were part of an animal
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tissue
excretion
therapeutic
clinical trials
placebo
tissue
![]()
excretion
(The correct answer is: 'tissue') ![]()
therapeutic
(The correct answer is: 'tissue') ![]()
clinical trials
(The correct answer is: 'tissue') ![]()
placebo
(The correct answer is: 'tissue') ![]() |
4. Removal of a by-product from the body
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tissue
excretion
therapeutic
clinical trials
placebo
tissue
(The correct answer is: 'excretion') ![]()
excretion
![]()
therapeutic
(The correct answer is: 'excretion') ![]()
clinical trials
(The correct answer is: 'excretion') ![]()
placebo
(The correct answer is: 'excretion') ![]() |
5. Testing the effects of a new substance on people
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tissue
excretion
therapeutic
clinical trials
placebo
tissue
(The correct answer is: 'clinical trials') ![]()
excretion
(The correct answer is: 'clinical trials') ![]()
therapeutic
(The correct answer is: 'clinical trials') ![]()
clinical trials
![]()
placebo
(The correct answer is: 'clinical trials') ![]() |