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Narrow-spectrum antibiotics

Antibiotics that only affect a specific family of pathogenic bacteria.

Communicable disease

Diseases that can be transmitted from one individual to another.

Antibiotic resistance

The evolution of strains of bacteria that are not affected by a particular antibiotic as a result of natural selection.

Natural selection

The process in nature where the fittest individuals survive, reproduce and pass their characteristics on to their offspring.

Eukaryotic cells

Cells that make up animals, plants, fungi and protista. They are three-dimensional, membrane-bound sacs containing cytoplasm, a nucleus and a range of membrane-bound organelles.

Immune system

The body's natural defence mechanism against infectious diseases.

prokaryotic

A unicellular organism that lacks a membrane bound nucleus or any other membrane bound organelle.

Prokaryotes

A group of single-celled organisms with few organelles and where the genetic material is not contained in a membrane-bound nucleus. They include bacteria and blue-green algae (cyanobacteria).

Mutation

A change in the arrangement or amount of genetic material in a cell.

Enzyme

Reusable protein molecules which act as biological catalysts, changing the rate of chemical reactions in the body without being affected themselves

Treating communicable diseases

Communicable diseases cause millions of deaths globally every year. They are caused by pathogens and can be passed from one individual to another. A wide variety of organisms cause communicable diseases, ranging from tiny, geometric viruses to parasitic worms that can grow many metres long inside our bodies. The symptoms of disease result from how of our bodies respond to the invasion of these foreign organisms. Here is a summary of some of the features of common pathogens – to find out more see Pathogens and the immune system.

Type of pathogen Main features Examples of disease
Bacteria Structure of a bacterium Some bacteria invade and destroy the cells. Many produce toxins that cause disease. Endotoxins act locally, affecting the cells directly around the bacterium. Exotoxins are released into the body of the host as the bacteria grow and reproduce, travelling around the body causing disease. Tonsillitis, septicaemia, pneumonia and tuberculosis (TB)
Viruses Structure of a virus Viruses are a combination of genetic material and protein that can invade living cells. They take over the biochemistry of the cells they invade to make more viruses, often destroying the host cells. Common cold, influenza, chickenpox, polio, HIV/AIDS
Fungi Structure of a fungal hypha Fungi do not cause many human diseases. There are a number of fungal skin conditions, and a few very serious conditions when a fungus attacks internal organs such as the brain or the lungs. Athlete’s foot, ringworm, aspergillosis
Protozoa Structure of a malaria parasite at one stage of the life cycle Protozoa act as parasites and cause human disease. They have two stages in their lifecycle so spend time in humans and another host that acts as a vector. Malaria, amoebic dysentery, sleeping sickness

Treating communicable diseases

To cure communicable diseases, medicines must either:

  • destroy or damage the pathogens that cause disease
  • prevent the pathogens from growing and reproducing

There are a number of different medicines that we can use against pathogens – but viruses and protozoa are very difficult to destroy.

Bacteria and antibiotics

Bacteria are prokaryotes and there are many features of prokaryotic cells that are different from our eukaryotic cells. Antibiotics are drugs that target bacteria and cure bacterial diseases. Many of their actions affect only bacterial cells, they either kill the bacteria or stop them growing but they do not destroy our human cells.

One way of classifying bacteria is by the way they take up Gram staining – they are known as Gram positive and Gram negative bacteria. The way they take up stain is affected by the structure of their cell walls. The structure of the cell walls also affects how sensitive a bacterium is to different antibiotics – there are some antibiotics that only affect Gram positive bacteria, and others that only affect the Gram negative species. The animation below demonstrates how the different antibiotics affect a bacterium.

Gram positive and Gram negative cell walls

The structural differences between the cells walls of Gram positive and Gram negative bacteria affect the way they take up stain – and the way they are affected by antibiotics

Some antibiotics are bacteriocidal – they kill the bacteria. Others are bacteriostatic – they prevent the bacteria from growing and this enables the immune system to recognise and destroy the pathogens. It will often depend mainly on the dosage used whether an antibiotic is bacteriostatic or bacteriocidal.

Some antibiotics affect a wide range of different bacteria. They are known as broad spectrum antibiotics. Others only destroy one or two species of bacteria – they are called narrow-spectrum antibiotics.

Antibiotic resistance

When antibiotics were first discovered and developed, people thought that infectious diseases caused by bacteria would become a thing of the past. There are a number of reasons why this hasn’t happened including:

  • Bacterial diseases affect people all over the world, and many countries have not had the money to afford antibiotic medicines or the health infrastructure to deliver them to the general population
  • Bacteria reproduce fast and mutate frequently. As a result they develop resistance to antibiotics by natural selection.

Antibiotics are only effective if the target microorganism has a binding site for the drug or a metabolic process that the antibiotic interferes with. Mutations that arise during bacterial reproduction may result in phenotypic features that make the bacteria resistant to the drug. For example by making the cell wall impermeable to the drug, changing a biochemical pathway or the production of an antibiotic-destroying enzyme. These mutations will be selected for when the antibiotic is used as they enable the bacteria with the mutation to survive and reproduce when others around them are dying.

Antibiotic resistance has become a major problem – many common antibiotics are now almost useless in many developed countries. Some bacteria have developed resistance to many different antibiotics. If someone is infected by one of these multi-resistant bacteria, it can be a death sentence.

What is more, the numbers of new antibiotics being developed has been falling steadily. This is partly because it is becoming harder to find new compounds that are effective against bacteria, and partly because the potential financial return is lower because new antibiotics will be used very sparingly to try and avoid future resistance developing.

Graph showing the reduction in the numbers of antibiotics produced over time.

Graph showing the reduction in the numbers of antibiotics produced over time.

Factors increasing the risk of antibiotic resistance
  • Overuse of antibiotics – the more antibiotics are used, the more opportunities there are for resistant strains to evolve
  • Non-compliance – patients often stop taking their antibiotics either because they decide they are not working, or because they rapidly feel better and decide they do not need the medication any more.
Ways of preventing the development of antibiotic resistance in bacteria

Controlling the use of antibiotics reduces opportunities for pathogens to develop resistance.

  1. Reduce the number of antibiotics prescribed even for mild bacterial infections – most patients with minor infections seen by GPs will recover as quickly without antibiotics as they do with them.
  2. Develop a test for use in GP surgeries and hospitals to identify bacterial infections immediately so no antibiotics are prescribed for viral infections, and the correct antibiotic is prescribed for each type of bacterial infection.
  3. Patients must complete every course of antibiotics – stopping the drugs before the end of a course encourages the development of antibiotic resistance. Bacteria that have developed a weak resistance to an antibiotic would be killed by the end of the full course of treatment. But if the level of antibiotic in the body drops too soon this enables them to survive. Some of this population may well mutate again to become more resistant to the antibiotic in future.

More resources

e-bug (www.e-bug.eu) is a free educational resource produced by Public Health England for classroom and home use and makes learning about micro-organisms, the spread, prevention and treatment of infection fun and accessible for all students.