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Monoclonal antibodies

Antibodies all made from a single clone of specialist cells used in both medical diagnostics and treatments

Human growth hormone

A hormone produced by the pituitary gland. Its best-known function is to affect growth in height of children.

Genetic engineering

Genetic engineering involves changing the DNA of an organism, usually by deleting, inserting or editing a gene to produce desired characteristics.

Active ingredient

The chemical which is the actual drug.

Antibiotic

Medicine that acts against bacterial infections. Penicillin is an example of an antibiotic.

Rejection

The process by which the immune system of the body can reject a transplanted organ

Bacteria

Single-celled organism. Has a cell wall, cell membrane, cytoplasm. Its DNA is loosely-coiled in the cytoplasm and there is no distinct nucleus

Enzyme

Reusable protein molecules which act as biological catalysts, changing the rate of chemical reactions in the body without being affected themselves

Insulin

A hormone produced by the pancreas. It allows cells in the body to take in and store glucose.

Asthma

A condition where the airways of the lungs narrow in response to an environmental or internal trigger making it difficult to breathe

Fungi

Fungi (singular fungus) are either uni-cellular, as in yeasts, or multi-cellular, as in mushrooms, toadstools and moulds. Fungi have a nucleus, cytoplasm and a cell wall

DNA

Deoxyribonucleic acid. This is the molecule which contains the genetic code. It coils up tightly inside chromosomes. DNA is a double helix made from two strands which are joined together by pairs of bases.

Primary manufacturing

The first stage of making a medicine is to manufacture the active ingredient.We call this stage the primary manufacture.The active pharmaceutical ingredient (API) will normally make up a small proportion of the final medicine. However this is the part that will treat the disease.

There are two main ways of developing the active ingredient

  • chemical technology
  • biotechnology

Developing the process to manufacture the active ingredient  requires skilled chemists and chemical engineers to investigate alternative chemical reactions to find out which makes the product they want in the highest yield and purity. They also have to consider the environment. So the solvents used will, wherever possible, be water based and energy consumption will be minimised. During research and development the chemical rections will have been scaled up in a pilot plant similar to the one shown in the virtual tour below.

Virtual tour of a pilot plant

Chemical Technology

Primary manufacture often involves chemical reactions to create new molecules.There can be many stages to these reactions.The diagram below shows a simple example in which two ingredients are reacted together.

One of the products of this reaction is the active ingredient. However there are other products as well.The chemists need to isolate and purify the active ingredient using a variety of techniques.

In our example, the active ingredient is in a solution so the mixture can be filters to remove any unwanted residues.The active ingredient will then crystallise when the solvent is allowed to evaporate. Sometimes there will need to be more stages before a completely pure sample is produced.

Many medicines are based on active ingredients made using chemical processes. The products are generally relatively small molecules such as those used for treatment of asthma, heart disease and pain. Some antibiotics, used to treat bacterial infections, may have a biotechnology product as one of their raw materials. This is then reacted with chemicals to create the antibiotic.

Sometimes an alternative biological process can be used to make the active ingredient; this is known as biotechnology.

Biotechnology

Biotechnology is the industrial use of  biological material. This means that living materials are usedin the manufacture of ingredients. Using biotechnology to make medicines started when penicillin was extracted from the mould Penicillin notatum in the 1930s, but biotechnology has been used for brewing and making cheese for hundreds of years.

More recently, scientists have modified the genes of bacteria so that they can produce useful proteins for use as medicines. By the 1980s there were bacteria making human insulin for the treatment of diabetes and also human growth hormone. This technique is called genetic engineering. You can learn more about this process in the Genes and Inheritance topic.

Genetic engineering allows scientists to introduce new genes that will make useful proteins into the DNA of cells.These cells may be bacteria, fungi, or cultures of animal cells.The modified cells can be grown on a large scale to produce large quatities of proteins. These products are known as biopharmaceuticals or biologics. They may be vaccines, hormones, enzymes or monoclonal antibodies. Monoclonal antibodies help to prevent rejection of transplants, and can be used to diagnose and treat some types of cancer and can be used to treat other diseases such as arthritis..