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Quiz: unravelling the genome

Test your knowledge of the Human Genome Project and the associated science with this on-line quiz. Select the correct answer from the multi-choices. When you have answered all 8 questions you may check your answers by clicking the button below.

1. How long did the Human Genome Project take to complete the first ever sequencing of the human genome?
11 years
13 years
15 years
17 years
11 years
The correct answer is b) – it was expected to take 15 years but advances in sequencing technology speeded the process up considerably.
13 years
- it was expected to take 15 years but advances in sequencing technology speeded the process up considerably.
15 years
The correct answer is b) – it was expected to take 15 years but advances in sequencing technology speeded the process up considerably.
17 years
The correct answer is b) – it was expected to take 15 years but advances in sequencing technology speeded the process up considerably.
2. Approximately how many genes in the human genome code for specific proteins?
19,000
100,000
250,000
25,000
19,000
– perhaps fewer than you might imagine – and fewer than the scientists first estimated at the end of the Human Genome Project!
100,000
The correct answer is a) 19,000 – perhaps fewer than you might imagine – and fewer than the scientists first estimated at the end of the Human Genome Project!
250,000
The correct answer is a) 19,000 – perhaps fewer than you might imagine – and fewer than the scientists first estimated at the end of the Human Genome Project!
25,000
The correct answer is a) 19,000 – perhaps fewer than you might imagine – and fewer than the scientists first estimated at the end of the Human Genome Project!
3. The Human Genome Project is an example of international scientific cooperation. How many countries were involved in sequencing the DNA?
5
11
15
18
5
The correct answer is d) 18 – they include the US, the UK, Australia, France…
11
The correct answer is d) 18 – they include the US, the UK, Australia, France…
15
The correct answer is d) 18 – they include the US, the UK, Australia, France…
18
– they include the US, the UK, Australia, France…
4. During the sequencing process an enzyme is used to build up DNA fragments. The enzyme used is
DNA ligase
DNA polymerase
restriction endonuclease
salivary amylase
DNA ligase
The correct answer is b) DNA polymerase which builds up DNA molecules during normal replication.
DNA ligase joins the sticky ends in genetic engineering.
Restriction endonucleases cut segments out of the genome in genetic engineering.
Salivary amylase is a digestive enzyme produced in the mouth.
DNA polymerase
- it builds up DNA molecules during normal replication.
DNA ligase joins the sticky ends in genetic engineering.
Restriction endonucleases cut segments out of the genome in genetic engineering.
Salivary amylase is a digestive enzyme produced in the mouth.
restriction endonuclease
The correct answer is b) DNA polymerase which builds up DNA molecules during normal replication.
DNA ligase joins the sticky ends in genetic engineering.
Restriction endonucleases cut segments out of the genome in genetic engineering.
Salivary amylase is a digestive enzyme produced in the mouth.
salivary amylase
The correct answer is b) DNA polymerase which builds up DNA molecules during normal replication.
DNA ligase joins the sticky ends in genetic engineering.
Restriction endonucleases cut segments out of the genome in genetic engineering.
Salivary amylase is a digestive enzyme produced in the mouth.
5. During the sequencing process different length fragments of DNA are produced. They are labelled with different coloured fluorescent tags depending on the final base attached. The terminating bases which halt the DNA synthesis are known as:
nucleotide bases
adenine
dideoxynucleotide bases
uracil
nucleotide bases
The correct answer is c) dideoxynucleotide bases – when they are added at random the terminate the synthesis sequence.
Nucleotide bases are normal nitrogenous bases which go to make up the DNA strand, adenine is an example of a nucleotide and uracil is a base found only in RNA.
adenine
The correct answer is c) dideoxynucleotide bases – when they are added at random the terminate the synthesis sequence.
Nucleotide bases are normal nitrogenous bases which go to make up the DNA strand, adenine is an example of a nucleotide and uracil is a base found only in RNA.
dideoxynucleotide bases
– when they are added at random the terminate the synthesis sequence.
Nucleotide bases are normal nitrogenous bases which go to make up the DNA strand, adenine is an example of a nucleotide and uracil is a base found only in RNA.
uracil
The correct answer is c) dideoxynucleotide bases – when they are added at random the terminate the synthesis sequence.
Nucleotide bases are normal nitrogenous bases which go to make up the DNA strand, adenine is an example of a nucleotide and uracil is a base found only in RNA.
6. The fluorescently labelled DNA fragments are separated by a process known as:
chromatography
spectrometry
centrifugation
gel electrophoresis
chromatography
The correct answer is d) gel electrophoresis – the DNA fragments are placed on a gel and move in an electric field. The shortest fragments move furthest.
Chromatography is a simpler separation of substances using a solid phase and a solvent travelling over it.
Spectrometry is the analysis of chemicals in special machines known as spectrometers.
Centrifugation involves the separation of different fractions as a result of spinning a mixture at high speed.
spectrometry
The correct answer is d) gel electrophoresis – the DNA fragments are placed on a gel and move in an electric field. The shortest fragments move furthest.
Chromatography is a simpler separation of substances using a solid phase and a solvent travelling over it.
Spectrometry is the analysis of chemicals in special machines known as spectrometers.
Centrifugation involves the separation of different fractions as a result of spinning a mixture at high speed.
centrifugation
The correct answer is d) gel electrophoresis – the DNA fragments are placed on a gel and move in an electric field. The shortest fragments move furthest.
Chromatography is a simpler separation of substances using a solid phase and a solvent travelling over it.
Spectrometry is the analysis of chemicals in special machines known as spectrometers.
Centrifugation involves the separation of different fractions as a result of spinning a mixture at high speed.
gel electrophoresis
– the DNA fragments are placed on a gel and move in an electric field. The shortest fragments move furthest.
Chromatography is a simpler separation of substances using a solid phase and a solvent travelling over it.
Spectrometry is the analysis of chemicals in special machines known as spectrometers.
Centrifugation involves the separation of different fractions as a result of spinning a mixture at high speed.
7. The findings of the Human Genome Project are expected to have many positive benefits to medicine and health. Which of these developments is NOT linked to the sequencing of the human genome?
improvements in diagnostic testing
development of drugs which are specifically targeted to the genetic makeup of the patient
the development of new synthetic materials for use in artificial joints
the growth of gene therapy as ways of identifying and then modifying faulty genes are found.
improvements in diagnostic testing
The correct answer is c) the development of new synthetic materials for use in artificial joints. All of the other developments are closely linked to the unravelling of the human genome.
development of drugs which are specifically targeted to the genetic makeup of the patient
The correct answer is c) the development of new synthetic materials for use in artificial joints. All of the other developments are closely linked to the unravelling of the human genome.
the development of new synthetic materials for use in artificial joints
All of the other developments are closely linked to the unravelling of the human genome.
the growth of gene therapy as ways of identifying and then modifying faulty genes are found.
The correct answer is c) the development of new synthetic materials for use in artificial joints. All of the other developments are closely linked to the unravelling of the human genome.
8. Approximately what percentage of the human genome codes directly for proteins?
less than 2%
10%
50%
more than 80%
less than 2%
The rest of the genome, known as non-coding DNA, has a variety of functions, which include regulating which proteins are made, when they are made, and how they are packaged. There is still a great deal to discover about the role of the non-coding DNA!
10%
The correct answer is a). Less than 2% of the genome gives instructions for the synthesis of specific proteins. The rest of the genome, known as non-coding DNA, has a variety of functions, which include regulating which proteins are made, when they are made, and how they are packaged. There is still a great deal to discover about the role of the non-coding DNA!
50%
The correct answer is a). Less than 2% of the genome gives instructions for the synthesis of specific proteins. The rest of the genome, known as non-coding DNA, has a variety of functions, which include regulating which proteins are made, when they are made, and how they are packaged. There is still a great deal to discover about the role of the non-coding DNA!
more than 80%
The correct answer is a). Less than 2% of the genome gives instructions for the synthesis of specific proteins. The rest of the genome, known as non-coding DNA, has a variety of functions, which include regulating which proteins are made, when they are made, and how they are packaged. There is still a great deal to discover about the role of the non-coding DNA!