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Cell biology

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Cell membranes

Cell membranemembrane
A thin, flexible sheet-like structure that acts as a lining or a boundary in an organism.
s are vital to the way cells function. In animal cells, they form the outer layer of the cell – the ultimate barrier between the inside of the cell and its surroundings. In plant cells, the cell surface membrane is inside a relatively rigid cellulosecellulose
A complex carbohydrate which makes up plant cell walls.
cell wall but the properties of the membrane still control much of what moves into and out of the cell. Most of the organellesorganelles
A distinct part of the cell, such as the nucleus, ribosome or mitochondrion, which has structure and function.
inside a eukaryoticeukaryotic
Cells that make up animals, plants, fungi and protista. They are three-dimensional, membrane-bound sacs containing cytoplasm, a nucleus and a range of membrane-bound organelles.
cell are also membrane-bound. Understanding the properties of cell membranecell membrane
The membrane which forms the boundary between the cytoplasm of a cell and the medium surrounding it and controls the movement of substances into and out of the cell.
s is key to understanding how cells work.

 

The structure of the cell membranemembrane
A thin, flexible sheet-like structure that acts as a lining or a boundary in an organism.

Our current model of the cell membranemembrane
A thin, flexible sheet-like structure that acts as a lining or a boundary in an organism.
has been built up over many years by a combination of experimental data and electron microscopy.

 

The unit membraneunit membrane
Bilayer of polar lipid molecules in an aqueous environment - the basis of the structure of the cell membrane.

The basic structure of the cell membranecell membrane
The membrane which forms the boundary between the cytoplasm of a cell and the medium surrounding it and controls the movement of substances into and out of the cell.
is a bilayer of phospholipidphospholipid
A lipid molecule with a hydrophilic region around the ionic phosphate group and a long hydrophobic hydrocarbon tail that forms a bilayer in aqueous solutions.
s. Phospholipid molecules have a hydrophilichydrophilic
Molecules that absorb or dissolve in water - usually polar molecules.
 ‘head’ region around the ionic phosphate groupphosphate group
A molecule containing phosphorus and oxygen.
 and a long hydrophobichydrophobic
Insoluble in water, repel water.
 hydrocarbon tail. These polar lipids form a bilayer in aqueous solutions with the hydrophilic heads pointing outwards and the hydrophobic tails forming a hydrophobic layer in the middle. This bilayer is known as a unit membrane.

Individ. Phospholipid
Unit Membrane

The cell membranemembrane
A thin, flexible sheet-like structure that acts as a lining or a boundary in an organism.

The cell membranecell membrane
The membrane which forms the boundary between the cytoplasm of a cell and the medium surrounding it and controls the movement of substances into and out of the cell.
, however, is more than a simple unit membraneunit membrane
Bilayer of polar lipid molecules in an aqueous environment - the basis of the structure of the cell membrane.
. Our current model is of a fluid phospholipidphospholipid
A lipid molecule with a hydrophilic region around the ionic phosphate group and a long hydrophobic hydrocarbon tail that forms a bilayer in aqueous solutions.
bilayer with many other molecules associated with it, floating or embedded in the lipid sea. These other molecules include cholesterolcholesterol
A lipid which can be measured in the blood. High levels are linked to an increased risk of cardiovascular disease.
, glycolipidsglycolipids
Lipids that have a carbohydrate chain attached to them. The carbohydrate chain is attached to the outside of the cell and is part of the cell recognition system.
, proteins and glycoproteinsglycoproteins
Proteins that have a carbohydrate chain attached to them. The carbohydrate chain sticks out of the outside of the cell and is part of the cell recognition system.
and they all have different functions in the membrane. This is the fluid mosaic modelfluid mosaic model
Our current model of membrane structure consisting of a fluid phospholipid bilayer with many other molecules (including cholesterol, glycolipids, proteins and glycoproteins) floating or embedded in the lipid sea, all with different functions.
of membrane structure and it explains many of the properties of membranes that we can observe experimentally.

 

Fluid Mosaic Model

The fluid mosaic model of the cell membrane.

 

  • A Phospholipids: lipid molecules with a hydrophilichydrophilic
    Molecules that absorb or dissolve in water - usually polar molecules.
    ‘head’ region around the ionic phosphate groupphosphate group
    A molecule containing phosphorus and oxygen.
    and a long hydrophobichydrophobic
    Insoluble in water, repel water.
    hydrocarbon tail that form a bilayer in aqueous solutions.
  • B Cholesterol: a lipid with a steroid ring structure, and hydrophilic and hydrophobic regions. It makes up part of the membrane structure - there may be up to one cholesterol molecule for every two phospholipids. Cholesterol makes the membrane stiffer and more rigid – so the amount of cholesterol in the structure affects the rigidity of the membrane.
  • C Glycolipids: lipids that have a carbohydratecarbohydrate
    Energy producing organic compounds which are made of carbon, hydrogen and oxygen. Examples of food containing carbohydrate are rice, pasta, bread and potatoes
     chain attached to them. The carbohydrate chain is attached to the outside of the cell and is part of the cell recognition system.
  • D Proteins: a wide variety of molecules that carry out many of the very specific functions of the cell membrane. There are integral proteins and peripheral proteins. They can form temporary and permanent channels in the membrane, allowing different molecules to pass in and out of the cell. They may be enzymes involved in active transportactive transport
    The process which uses energy to move substances against a concentration gradient or across a partially permeable membrane using a special transport protein.
    systems or enzymes linked to biochemical pathways such as photosynthesis or respiration. Proteins also act as receptor molecules for other molecules such as hormones and neurotransmittersneurotransmitters
    Chemicals which are released in a synapse when an action potential reaches the end of one neurone. They cross the synaptic gap and trigger and impulse in the next neurone.
    .
  • E Glycoproteins: proteins that have a carbohydrate chain attached to them. The carbohydrate chain sticks out of the outside of the cell and is part of the cell recognition system.

 

Functions of the cell membranemembrane
A thin, flexible sheet-like structure that acts as a lining or a boundary in an organism.

Many of the functions of the surface cell membranecell membrane
The membrane which forms the boundary between the cytoplasm of a cell and the medium surrounding it and controls the movement of substances into and out of the cell.
and membranes around cell organellesorganelles
A distinct part of the cell, such as the nucleus, ribosome or mitochondrion, which has structure and function.
are similar, although there are some which are specific to the outer membrane.

  • Membranes form partially permeablepartially permeable
    Permeable to some substances but not to others.
    barriers between the cell and its environment, between organelles and the cytoplasm and within organelles. They control the movement of substances both into and out of the cell and into and out of organelles. Permanent and temporary protein pores are involved in this control, as well as permanent and temporary active transportactive transport
    The process which uses energy to move substances against a concentration gradient or across a partially permeable membrane using a special transport protein.
    systems. Some channels are gated – they can be opened or closed depending on conditions inside or outside of the cell as described on the next page.
  • Membranes are the site of many chemical reactions because the enzymes involved are embedded in the membrane structure. Reactions take place both on the cell surface membrane and on the membranes in organelles such as mitochondriamitochondria
    Organelle(s) within cells that produce ATP, used as a store of chemical energy. Often called the cell's powerhouse
     and chloroplasts.
  • Membranes are important in the development of chemical and electrochemical gradients – for example those involved in nerve impulses and in the production of ATP by chemiosmosis.
  • Membranes are the site of cell identification. The carbohydratecarbohydrate
    Energy producing organic compounds which are made of carbon, hydrogen and oxygen. Examples of food containing carbohydrate are rice, pasta, bread and potatoes
    markers attached to glycoproteinsglycoproteins
    Proteins that have a carbohydrate chain attached to them. The carbohydrate chain sticks out of the outside of the cell and is part of the cell recognition system.
    and glycolipidsglycolipids
    Lipids that have a carbohydrate chain attached to them. The carbohydrate chain is attached to the outside of the cell and is part of the cell recognition system.
    along with some membrane proteins act as antigenantigen
    A protein, nucleic acid, or other molecule, which can stimulate a response from the immune system.
    s, identifying one cell to other cells. For example this system enables the cells of the immune systemimmune system
    The body's natural defence mechanism against infectious diseases.
    to identify pathogens, cells from other organisms of the same species (eg after an organ transplanttransplant
    The process of replacing a damaged or diseased organ with a healthy organ from a dead or living donor.
    ), abnormal body cells (eg cancer cells) and toxins produced by pathogens.
  • Membranes are the site of cell communication. Cell signalling takes place between cells through the protein receptor molecules in the cell surface membrane and within cells; for example in the passing of hormone messages from the body to the nucleus of the cell and the movement of mRNA out of the nucleus through nuclear membranenuclear membrane
    The thin, flexible structure enclosing the contents of the nucleus in a cell.
    pores. This process is described in more detail later.

The pores in the nuclear membrane allow chemicals to move into the nucleus and mRNA to move out into the cytoplasm. (Image courtesy of Don W. Fawcett/Hector E. Chemes/Bernard Gilula (CC BY-NC-ND 3.0))

Activity

Use materials of your choice – anything from plasticine to plastic bottles and beyond – make a three-dimensional model of the cell membrane that can be used to explain the structure and functions of this amazing structure.