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Biology
Chemistry
Science
Human biology
Biology
Biology
Science (applied)
Chemistry
Biology
Around 18% of the human body is made of protein – second only in mass to water. Proteins are important in living organisms in many ways including:
Like carbohydratecarbohydrate
Energy producing organic compounds which are made of carbon, hydrogen and oxygen. Examples of food containing carbohydrate are rice, pasta, bread and potatoes
s and lipids, proteins include the elements carbon, hydrogen and oxygen but proteins also all contain nitrogen. Many proteins also contain sulfur and some include phosphorus and other elements.
Proteins are both macromoleculesmacromolecules
Very large molecules, often formed by the polymerisation of smaller subunits, e.g., proteins, nucleic acids and carbohydrates.
and polymers – they are built up of long chains of monomers called amino acidamino acid
The basic building blocks of proteins. There are twenty amino acids used, in different combinations, to make every protein required by the human body.
s.
Nine of these are essential amino acids – we must eat them in our diets as we cannot synthesise them in our bodies. Eleven of the amino acids are non-essential; although we usually get them from our food we can synthesise them if we need to.
All amino acids have the same basic structure with an amino groupamino group
Nitrogen containing NH2 group found in all amino acids.
(-NH2) and a carboxyl groupcarboxyl group
Acidic -COOH group found in all amino acids.
(-COOH) attached to the same carbon atom, along with a hydrogen atom and a variable group often referred to as the R group. The carboxyl end is acidic and the amino end is basic (i.e. has the properties of a base, can accept a proton H+ ion) in nature so amino acids are amphoteric – they can act as acids or bases. The R group – see below – also affects the nature of the amino acid and has a big effect on the structure of proteins.
Structure of an amino acidamino acid
The basic building blocks of proteins. There are twenty amino acids used, in different combinations, to make every protein required by the human body.
Although the R group is important in the structure of proteins, it is ignored when considering how amino acidamino acid
The basic building blocks of proteins. There are twenty amino acids used, in different combinations, to make every protein required by the human body.
s join together to form proteins.
Amino acids are joined in a reaction between the amino groupamino group
Nitrogen containing NH2 group found in all amino acids.
of one amino acid and the carboxyl groupcarboxyl group
Acidic -COOH group found in all amino acids.
of another. This is a condensation reaction which results in a bond known as a peptide bond (or peptide link). Two amino acids joined form a dipeptide. As more and more amino acids are joined into the chain it becomes a polypeptidepolypeptide
A long chain of hundreds or even thousands of amino acids joined by peptide bonds.
chain, which may contain hundreds or even thousands of amino acids. A protein is a polypeptide chain which is folded or coiled or associated with other polypeptide chains.
Peptide bonds are broken in a hydrolysis reaction to release the amino acids.
Amino acids are joined together to form polypeptides and proteins by peptide bonds.